Tramadol Retard Zentiva 150 mg


Tramadol Retard Zentiva 150 mg online


Tramadol Retard Zentiva 150 mg is a prolonged-release formulation of tramadol hydrochloride, a centrally acting analgesic used for the treatment of moderate to severe pain. The “retard” in the name indicates that it is a sustained-release formulation designed to release the drug gradually over time, providing longer-lasting pain relief.

Key Information

  • Active Ingredient: Tramadol hydrochloride
  • Strength: 150 mg per tablet
  • Formulation: Prolonged-release tablet
  • Brand: Zentiva


Tramadol Retard Zentiva 150 mg is indicated for the management of moderate to severe pain in adults that requires continuous, around-the-clock treatment for an extended period.

Mechanism of Action

Tramadol works by binding to the mu-opioid receptors in the brain and inhibiting the reuptake of norepinephrine and serotonin, which modulates the perception of pain.

Dosage and Administration

  • Initial Dose: The typical starting dose for adults is one 150 mg prolonged-release tablet taken once daily.
  • Titration: The dose may be adjusted based on the patient’s response and pain severity. It is important to follow the prescribing doctor’s instructions.
  • Administration: Tablets should be swallowed whole with water and should not be split, crushed, or chewed to maintain the prolonged-release properties.


  • Hypersensitivity: Patients with known hypersensitivity to tramadol or any other components of the formulation.
  • Acute Intoxication: Patients with acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids, or psychotropic drugs.
  • Respiratory Depression: Patients with severe respiratory depression.
  • Monoamine Oxidase Inhibitors (MAOIs): Concomitant use with MAOIs or within 14 days of discontinuing them.


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